Starting from $550

Polynucleotides

Regenerative skin therapy using PDRN to repair, hydrate, and rebuild ageing skin at a cellular level.

What it is

Polynucleotides (PDRN) represent one of the most exciting advances in regenerative aesthetics. Derived from salmon DNA, these biocompatible compounds stimulate tissue repair, reduce inflammation, and enhance the skin's natural regenerative capacity at a cellular level. Unlike hyaluronic acid treatments that primarily hydrate, polynucleotides work by activating fibroblasts and promoting angiogenesis — improving blood supply, wound healing, and collagen synthesis from the inside out. The result is skin that looks and feels fundamentally healthier: more even, more resilient, and genuinely rejuvenated. For menopausal women dealing with thinning, fragile, or slow-healing skin, polynucleotides offer a regenerative approach that works with the body's own repair mechanisms.

How hormones shape this treatment

Menopausal skin not only produces less collagen but also loses its ability to repair itself efficiently. Reduced oestrogen impairs fibroblast function, slows wound healing, and decreases the skin's natural regenerative activity. Polynucleotides directly address this by activating fibroblasts and supporting cellular repair pathways — making them particularly well-suited for the specific changes menopause brings, including skin thinning, crepiness, loss of firmness, and increased sensitivity.

What to expect

A consultation to assess whether polynucleotides are the most appropriate regenerative treatment for your skin concerns
Topical numbing applied before treatment for comfort
A series of small injections across the treatment area — typically the face, under-eye area, neck, or décolletage
Mild swelling and temporary papules that resolve within 24–48 hours
Gradual improvement over 4–8 weeks as cellular regeneration occurs; a course of three sessions is recommended

Your investment

$550per session

Course of 3 sessions recommended · from $550 per session · face, neck, and under-eye available

A $50 refundable deposit secures your appointment — applied to your treatment cost and fully refundable with 48 hours' notice.

Consultation required before treatment — your safety comes first.

Your doctors

London-trained doctors behind every treatment

This treatment is delivered by our London-trained medical team — Dr. Sundeep Varma (MUDr · MRCGP · DFSRH) and Dr. Hemel Mandalia (BDS · MSc). Every protocol is physician-supervised from consultation through to follow-up.

Meet the doctors behind London & Glow →

Results may vary. A consultation is required before treatment. This service is an aesthetic treatment and does not constitute medical treatment for menopause.

Frequently Asked Questions

Polynucleotides are chains of nucleotides — the building blocks of DNA — derived from salmon or trout. When injected into the skin, they stimulate fibroblast activity, promote collagen and elastin synthesis, and accelerate tissue repair. They are highly biocompatible and have been used in regenerative medicine for decades.

Skin boosters primarily provide hydration via hyaluronic acid. Polynucleotides work at a cellular regenerative level — they do not add hydration directly, but stimulate the skin's own repair and production mechanisms. For some patients, we recommend both as part of a comprehensive programme.

Polynucleotides work gradually. Many patients notice improved skin texture and a subtle lift in skin quality within four weeks; the full benefit is typically visible after a course of three treatments and continues to improve for several months thereafter.

Yes — polynucleotides are particularly well suited to the delicate under-eye area, where they can improve fine lines, dark circles related to skin thinning, and the crepe-like texture that develops with hormonal ageing.

Pre-treatment: avoid aspirin, ibuprofen, and blood-thinning supplements for one week, and alcohol for 24 hours. Post-treatment: mild swelling and small injection bumps are normal and resolve within 24–48 hours. Avoid vigorous exercise for 24 hours, sun exposure for 48 hours, and apply SPF 50 daily.

What to expect at your first visit

Every journey with us begins with an unhurried consultation. Here's exactly what happens when you come in.

A warm welcome

You'll be welcomed by your physician in a calm, private room — no rushed waiting area, no pressure. This time is entirely yours.

Understanding you

We begin with a conversation about your goals, health history, skin concerns, and where you are in your hormonal journey. Nothing is too small to mention.

Expert assessment

Your physician will examine your skin and facial anatomy under optimal lighting, explaining what they observe and how it relates to your concerns.

An honest treatment plan

We'll outline what we recommend, why, what results are realistic, and what the investment looks like — with no obligation to proceed on the day.

All your questions answered

There are no silly questions here. We want you to leave knowing exactly what's involved so you can make a fully informed decision in your own time.

Ready to book?

Your consultation is where we assess whether polynucleotides Edmonton are right for your skin, and design a regenerative programme around your individual concerns — physician-led aesthetics in the Brewery District.

Meet the doctors behind London & Glow →

Currently accepting new patients by appointment only — limited consultation availability.

Book your consultation